Author

Roch Tremblay

Hôpital Maisonneuve-RosemontORCID 0000-0003-1589-7407Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Organism:yeast· 1

Frequent Co-Authors

Antoine SimoneauiD· 1 shared Corey NislowiD· 1 shared El Bachir AffariD· 1 shared Guri N. GiaeveriD· 1 shared Hugo WürteleiD· 1 shared Mary E. McQuaidiD· 1 shared Oumaima AhmediD· 1 shared Yosra MehrjooiD· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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1 shared paperMolecular Biology

Antoine SimoneauORCID

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1 paper

Recent·Most cited

Molecular BiologyMolecular and Cellular BiologyPeer-reviewedOct 9, 2023

Persistent acetylation of histone H3 lysine 56 compromises the activity of DNA replication origins

Roch Tremblay, Yosra Mehrjoo, Oumaima Ahmed…·Hugo Würtele

The paper identifies DBF4 as a gene influencing cell fitness under sirtuin inhibition and shows that persistent H3 K56ac impairs DNA replication origin activity, leading to replicative stress.

4 citations

yeastDNA methylation

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