The paper identifies host genetic processes that influence Dsup's ability to confer cadmium resistance in yeast by screening deletion mutants under cadmium stress.

bioRxiv · Oct 3, 2026 · PreprintGenomics

Friend and Foe: Genome-Wide Analysis of the Tardigrade Dsup Protein Expressed in Yeast Reveals Trade-offs of DNA Protection

Hamid Kian Gaikani, Marjan Barazandeh, Lewis Hitchens, Guri N. Giaever, Corey Nislow

This study shows that Dsup protects yeast from DNA damage but has fitness costs and creates new dependencies on DNA repair pathways.

bioRxiv · Dec 25, 2025 · PreprintGenomics

A platform for the systematic interrogation of genetic interactions in human cells: 26 gene by genome-wide double knockout screens as a proof of concept

Andrew Chatr‐aryamontri, Li Zhang, Ndeye Khady Thiombane, Vincent Archambault, Sébastien Carreno, Javier Marcelo Di Noia, Ivan Topisirović, Julie A. Lessard, Philippe P. Roux, Nicolas Pilon, Aaron David Schimmer, Mike Tyers, Corey Nislow, Sylvie Mader, Brian T. Wilhelm, Thierry Bertomeu

The paper introduces a method for systematically studying genetic interactions in human cells using CRISPR/Cas9 screens and demonstrates its effectiveness through 26 gene by genome-wide knockout screens.

bioRxiv · Aug 4, 2025 · PreprintGenetics

Mining Yeast Diversity Unveils Novel Targets for Improved Heterologous Laccase Production in Saccharomyces cerevisiae

Ryan Wei Kwan Wong, Marissa Foo, Jasmine R. S. Lay, Tiffany L. T. Wai, Jackson Moore, Fabien Dutreux, Cristen M. Molzahn, Corey Nislow, Vivien Measday, Joseph Schacherer, Thibault Mayor

The paper identifies yeast strains with enhanced recombinant laccase production and characterizes genetic factors contributing to this trait.

bioRxiv · Aug 26, 2024 · PreprintMolecular Biology

Persistent acetylation of histone H3 lysine 56 compromises the activity of DNA replication origins

Roch Tremblay, Yosra Mehrjoo, Oumaima Ahmed, Antoine Simoneau, Mary E. McQuaid, El Bachir Affar, Corey Nislow, Guri N. Giaever, Hugo Würtele

The paper identifies DBF4 as a gene influencing cell fitness under sirtuin inhibition and shows that persistent H3 K56ac impairs DNA replication origin activity, leading to replicative stress.

Molecular and Cellular Biology · Oct 9, 2023Peer-reviewedMolecular Biology

Combining chemogenomic and gene-dose assays to investigate drug synergy

Hamid Kian Gaikani, Andrew M. Smith, Anna Y. Lee, Guri N. Giaever, Corey Nislow

This study combines chemogenomic and gene-dose assays to analyze drug synergy, identifying combination-specific sensitive strains that suggest mechanisms for observed synergies.

Frontiers in Fungal Biology · Jul 2, 2021Peer-reviewedGenomics

The Paf1 complex broadly impacts the transcriptome of Saccharomyces cerevisiae

Mitchell A. Ellison, Alex R. Lederer, Marcie H. Warner, Travis N. Mavrich, Elizabeth A. Raupach, Lawrence E. Heisler, Corey Nislow, Miler T. Lee, Karen M. Arndt

This study investigates the role of the Paf1 complex in regulating the transcriptome of Saccharomyces cerevisiae, revealing its impact on both coding and noncoding transcripts through transcriptional and post-transcriptional mechanisms.

Genetics · May 15, 2019Peer-reviewedGenomics