Guri N. Giaever

The paper identifies host genetic processes that influence Dsup's ability to confer cadmium resistance in yeast by screening deletion mutants under cadmium stress.

This study shows that Dsup protects yeast from DNA damage but has fitness costs and creates new dependencies on DNA repair pathways.

The paper identifies DBF4 as a gene influencing cell fitness under sirtuin inhibition and shows that persistent H3 K56ac impairs DNA replication origin activity, leading to replicative stress.

This study combines chemogenomic and gene-dose assays to analyze drug synergy, identifying combination-specific sensitive strains that suggest mechanisms for observed synergies.