Katherine Elena Varley

The paper characterizes thymic adipocyte heterogeneity and metabolic signatures in mice, identifying two distinct subpopulations with distinct transcriptional and chromatin features.

This paper shows that Dnmt3a-mediated DNA methylation is essential for maintaining lineage commitment and function of memory Th1 and Tfh cells, and that early inhibition of this process can enhance Tfh cell differentiation.

This paper introduces ScreenDL, a deep learning model that predicts effective cancer therapies using tumor omic and drug screening data, outperforming existing methods in preclinical trials.

The paper introduces HAPI, a 3D genomics method, to identify enhancer hijacking in cancer cell lines, revealing novel oncogene activation mechanisms.

The paper develops and validates a mammalian 2-hybrid assay to classify BRCA1 RING domain missense substitutions, finding 20% are pathogenic and classifying 89% of observed variants.

CaBagE is a method for enriching target DNA regions for long-read sequencing, achieving high coverage and enabling analysis of complex genomic loci in disease contexts.