Xiaoyang Zhang

This study investigates the differential roles of HNF4α isoforms P1 and P2 in PDAC growth and differentiation, finding P2 supports growth better than P1.

The paper identifies estrogen-induced chromatin looping changes in endometrial cancer cells and shows their correlation with transcriptional responses, though not all loops are essential for estrogen regulation.

This paper shows SS18::SSX fusion protein alters BAF chromatin remodeler distribution, leading to transcriptional activation and repression by changing histone modifications at regulatory regions.

This study identifies cis-regulatory elements that control transcriptional timing and noise in response to estrogen using single-cell RNA-seq and machine learning.