Joon Schwakopf

Foxp1 Coordinates Early Temporal Identity and Neurogenic Progression in Retinal Progenitors

This study identifies Foxp1 as a transcriptional regulator that coordinates early progenitor identity with neurogenic progression in the developing retina by activating early-stage genes and proneural factors while repressing late temporal factors.

Apoptosis at the optic fissure shapes transient retinal myeloid states

The paper identifies the optic fissure as the entry site for myeloid cells into the embryonic mouse retina, showing that apoptosis and CD206 expression are linked to transient myeloid states during development.

Molecular heterogeneity and differential metabolic signatures in thymic adipocytes

The paper characterizes thymic adipocyte heterogeneity and metabolic signatures in mice, identifying two distinct subpopulations with distinct transcriptional and chromatin features.

CD11c-expressing microglia are transient, driven by interactions with apoptotic cells

The paper identifies CD11c-expressing microglia as a transient state in the developing retina driven by interactions with apoptotic cells, not a specialized subset for phagocytic clearance.

Neuronal apoptosis drives remodeling states of microglia and shifts in survival pathway dependence

The paper investigates how interactions with apoptotic neurons influence microglial states and survival pathway dependence using scRNAseq in mouse retina.