João Delgado

This study identifies genetic variants causal for multiple long-term conditions, revealing shared biological pathways and potential drug targets while highlighting adverse effects of interventions.

This study integrates primary care and genetic data to identify multimorbidity patterns and shared genetics across 72 chronic conditions, revealing both concordant and discordant relationships.

This paper combines pharmacogenetic variants and polygenic scores for patient characteristics to improve prediction of clinical outcomes in Calcium Channel Blocker treatment.

This study finds that CYP2C19 loss-of-function variants are associated with increased risk of ischemic stroke and MI in patients on long-term clopidogrel therapy in primary care.

The paper re-evaluates the association between ApoE e4e4 genotype and COVID-19 test positivity and mortality in the UK Biobank cohort, finding increased risks for both outcomes compared to e3e3 genotype.

The paper investigates the association between ApoE e4 genotype and severe COVID-19 in the UK Biobank community cohort, finding a link with increased risk of severe outcomes.