Deniz Türkmen

This study identifies genetic variants causal for multiple long-term conditions, revealing shared biological pathways and potential drug targets while highlighting adverse effects of interventions.

This paper combines pharmacogenetic variants and polygenic scores for patient characteristics to improve prediction of clinical outcomes in Calcium Channel Blocker treatment.

This study finds that CYP2C19 loss-of-function variants are associated with increased risk of ischemic stroke and MI in patients on long-term clopidogrel therapy in primary care.

The paper introduces the TWIST framework for causal inference in pharmacogenetics, showing how to combine different estimation strategies to improve robustness and efficiency in estimating genetically moderated treatment effects.