Srinivasarao Repudi

This study identifies optimal parameters for neuron-targeted WWOX gene therapy in a mouse model of WWOX-related epileptic encephalopathy, showing durable rescue with a defined therapeutic window and dose.

This study identifies WWOX as a critical regulator of oligodendrocyte differentiation and myelin repair, showing its interaction with SOX10 and its role in myelin regeneration.

This study shows that gene therapy using an AAV vector to restore WWOX expression in neurons rescues multiple neurological defects in Wwox-null mice.

This study uses brain organoids to model WOREE, a severe epileptic encephalopathy, identifying CNS abnormalities and showing potential therapeutic rescue via WWOX expression.