Jing Guo

The SAS chromatin-remodeling complex establishes inflorescence-specific chromatin accessibility at distal promoter and upstream intergenic regions, enabling transcription factor binding during flower development.

This study identifies RNA polymerase II degradation as the driver of chromatin reorganization from non-surrounded nucleolus to surrounded nucleolus in mammalian oocytes.

The paper profiles somatic L1Hs insertions in Rett patients and healthy controls, finding increased insertions in the brain and altered genomic patterns linked to MECP2 dysfunction.