Ge Lin

This paper develops a non-invasive method for embryo quality assessment using metabolomics of spent culture media and machine learning, identifying metabolic signatures linked to ploidy and morphology.

This paper develops a rapid phosphopeptide enrichment method (Ti-PAN) for nanoscale samples, achieving high sensitivity and recovery, and identifies key kinases in oocyte maturation.

This study uses single-cell proteomics to identify protein changes in human oocytes during in vitro aging, revealing key biological processes and potential biomarkers.

This study identifies RNA polymerase II degradation as the driver of chromatin reorganization from non-surrounded nucleolus to surrounded nucleolus in mammalian oocytes.

The paper identifies CEP192 as a novel disease gene linked to mosaic variegated aneuploidy syndrome with tetraploidy and male infertility through genetic analysis and mouse models.

This study uses ultra-low coverage whole genome sequencing on embryo samples to perform GWAS and identifies genetic loci associated with gestational age.

The paper presents a method to accurately identify CNVs and mosaicism from few cells with low GC bias using a single-molecule sequencing platform.

This study uses Oxford Nanopore long-read sequencing to precisely localize breakpoints in balanced translocations and inversions, achieving single-base resolution for some cases.

The paper analyzes single-cell RNA-seq data from human embryos to compare gene expression between males and females, identifying differences in sex chromosome activation and dosage compensation during early development.

The paper introduces scCAT-seq, a method to simultaneously assay chromatin accessibility and transcriptome in single cells, and demonstrates its application in human pre-implantation embryos to reveal regulatory heterogeneity.