Bin Li

This study identifies RNA polymerase II degradation as the driver of chromatin reorganization from non-surrounded nucleolus to surrounded nucleolus in mammalian oocytes.

WEDGE imputes gene expression values in single-cell RNA-seq datasets using biased matrix decomposition, improving clustering and correlation recovery in sparse data.

The paper uses single-cell analysis to show that Tocilizumab reduces monocyte-driven inflammation in severe COVID-19 but does not fully suppress immune responses.

APEC improves single-cell chromatin accessibility analysis by clustering cells based on accessible regions and integrates with other tools to enhance clustering accuracy and predict gene expression and regulatory elements.