Author

Geertje van der Horst

Leiden University Medical CenterORCID 0000-0003-1696-160XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Alberto MalerbaiD· 1 shared Benedikt Mathias KessleriD· 1 shared Iolanda VendrelliD· 1 shared March· 1 shared Milad ShademaniD· 1 shared s Khoshbash· 1 shared Sarah Flannery· 1 shared Silvère M. van der MaareliD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperNeuroscience

Alberto MalerbaORCID

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1 paper

Recent·Most cited

NeurosciencebioRxivPreprintJun 16, 2026

Domain-specific regulation of PABPN1 uncouples aggregation from function and enables therapeutic rescue

Milad Shademan, Iolanda Vendrell, Alberto Malerba…·Vered Raz

This study identifies a stabilized PABPN1 variant, trPAB, that reduces aggregation and restores function in OPMD and bladder cancer models, supporting its potential as a gene therapy.

DOI 10.64898/2026.06.12.731084

humanproteomics

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