Milad Shademan

This study shows that the N-terminal truncation of USP18 generates a short isoform (SF) with distinct functions in muscle differentiation compared to the long isoform (LF).

This study identifies a stabilized PABPN1 variant, trPAB, that reduces aggregation and restores function in OPMD and bladder cancer models, supporting its potential as a gene therapy.

The paper identifies heparan sulfate (HS) as a key factor for cell-surface RNA (csRNA) presentation and reveals a ternary complex of HS, RNA, and RNA-binding proteins that recruits immune receptors.

This study correlates the structure of pathogenic and non-pathogenic PABPN1 protein aggregates with cellular function in differentiated muscle cells using multimodal imaging.

The paper investigates how PABPN1 loss-of-function in OPMD affects APA-shift in muscle transcripts, showing it is linked to reduced PABPN1 isoform expression rather than expanded PABPN1 levels.