Autophagy activity is inhibited by hnRNP R
The paper identifies hnRNP R as a nuclear RNA binding protein that inhibits autophagy by interacting with key autophagy proteins and shows depletion of hnRNP R activates autophagy flux.
Author
Universitätsklinikum WürzburgORCID 0000-0003-1762-3581Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
The paper identifies hnRNP R as a nuclear RNA binding protein that inhibits autophagy by interacting with key autophagy proteins and shows depletion of hnRNP R activates autophagy flux.
This study shows hnRNP R regulates stress granule formation by affecting their assembly and resolution, and its depletion leads to altered granule phenotypes and TDP43 granule formation.
Chunchu Deng, Mehri Moradi, Sebastian Reinhard…·Michael Sendtner
The paper investigates dynamic remodeling of endoplasmic reticulum and ribosomes in axons of motoneurons in response to BDNF stimulation, revealing their role in local translation and synapse maintenance.