Patrick Lüningschrör

Non-invasive peripheral delivery of CDNF fragment protects neurons in models of Parkinsons and ALS

This paper demonstrates that a novel C-CDNF fragment can protect neurons in Parkinson's and ALS models through non-invasive peripheral delivery.

Constitutively active TrkB kinase signalling reduces actin filopodia dynamics and cell migration

This study shows that constitutive TrkB kinase signalling, independent of ligand, reduces actin filopodia dynamics and cell migration, and can be inhibited by Trk inhibitors.

Dynamic remodeling of ribosomes and endoplasmic reticulum in axon terminals of motoneurons

The paper investigates dynamic remodeling of endoplasmic reticulum and ribosomes in axons of motoneurons in response to BDNF stimulation, revealing their role in local translation and synapse maintenance.

CDNF rescues motor neurons in three animal models of ALS by targeting ER stress

This study shows CDNF reduces ER stress and improves motor neuron survival in multiple ALS models, independent of genetic cause.