Magdalena Malm

The paper identifies transcriptomic signatures that explain most of the variation in recombinant protein yield in CHO cells producing 2165 human secretome proteins.

The paper compares transcriptomic profiles of HEK293 cell lines producing erythropoietin or GFP to identify factors associated with improved erythropoietin production.

The paper identifies secretory pathway differences between HEK293 and CHO cells that improve recombinant protein expression when switching hosts.

The paper analyzes genomic, transcriptomic, and metabolic changes in HEK293 cell lines to understand genetic and compositional differences between adherent and suspension derivatives.

The paper maps and characterizes the human secretome by annotating 2,623 predicted secreted proteins and their spatial distribution, using a high-throughput cell factory for recombinant protein production and analysis.