Author

Sophia Hober

KTH Royal Institute of TechnologyORCID 0000-0003-0605-8417Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Chih‐Chung Kuo· 3 shared Diane HattoniD· 3 shared Hanna TegeliD· 3 shared Johan RockbergiD· 3 shared Magdalena MalmiD· 3 shared Magnus LundqvistiD· 3 shared Nathan E. LewisiD· 3 shared Anna Berling· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersSystems Biology

Chih‐Chung Kuo

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3 papers

Recent·Most cited

Systems BiologybioRxivPreprintDec 12, 2022

Deciphering the determinants of recombinant protein yield across the human secretome

Helen O. Masson, Chih‐Chung Kuo, Magdalena Malm…·Nathan E. Lewis

The paper identifies transcriptomic signatures that explain most of the variation in recombinant protein yield in CHO cells producing 2165 human secretome proteins.

4 citations

mousebulk RNA-seq

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Systems BiologyMetabolic EngineeringPeer-reviewedMar 14, 2022

Harnessing secretory pathway differences between HEK293 and CHO to rescue production of difficult to express proteins

Magdalena Malm, Chih‐Chung Kuo, Mona Moradi Barzadd…·Johan Rockberg

The paper identifies secretory pathway differences between HEK293 and CHO cells that improve recombinant protein expression when switching hosts.

52 citations

humanbulk RNA-seq

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Molecular BiologybioRxivPreprintNov 27, 2018

The human secretome - the proteins secreted from human cells

Mathias Uhlén, Hanna Tegel, Åsa Sivertsson…·Sophia Hober

The paper maps and characterizes the human secretome by annotating 2,623 predicted secreted proteins and their spatial distribution, using a high-throughput cell factory for recombinant protein production and analysis.

13 citations

humanproteomics

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