Alexander V. Klimovich

This study uses optogenetics to show Hydra tissues integrate Wnt signaling over time, leading to pattern formation through cumulative transcriptional responses.

The paper integrates single-cell, spatial, and clonal data to study cranial placode development and evolution, revealing continuous transcriptional landscapes and shared progenitors between placodes.

This study investigates the evolutionary trends in skeletal cell type emergence, finding that lineage-specific genes drove the diversification of osteoblasts and hypertrophic chondrocytes from an ancestral chondrocyte-like state.

The paper shows that Hydra's microbiota influences stem cell decision making, affecting budding capacity through changes in chromatin and transcriptomic landscapes.

The paper constructs a model connectome for Hydra's N3 nerve net and shows it can generate both short-lived and persistent activity patterns related to behavior.

This study uses genetic interference to investigate HvNotch's role in Hydra development, revealing its impact on regeneration, patterning, and boundary formation.

The paper identifies and characterizes prototypical pacemaker neurons in Hydra that express immune-related genes and interact with the microbial environment.

This study identifies Fat-like and Dachsous cadherins in Hydra, showing their role in cell adhesion and planar polarity, suggesting ancient functions in bilaterian evolution.

The paper identifies anti-apoptotic functions of Bcl-2 and TMBIMP family proteins in Hydra, showing their conservation across metazoans.