Alek G. Erickson

The paper introduces clone2vec, a machine learning method for analyzing lineage-resolved single-cell data, revealing clonal patterns and continuous variation in development and disease.

The paper integrates single-cell, spatial, and clonal data to study cranial placode development and evolution, revealing continuous transcriptional landscapes and shared progenitors between placodes.

The paper profiles clonal landscapes in mouse embryos to reveal spatial modulators of clonal fate biases using single-cell lineage tracing and clone2vec.

This study shows that motor nerves guide the development of sympathetic ganglia by directing the migration and differentiation of neural crest-derived sympathoblasts.

The paper maps the regulatory landscape of neuronal and glial differentiation in the enteric nervous system using single-cell RNA sequencing and identifies gene modules and epigenetic memory associated with neurogenesis and gliogenesis.