Moritz Mercker

The paper introduces a mathematical model of Wnt-Dickkopf interactions in Hydra to explain body-axis formation through mutual inhibition, showing it can drive pattern formation across a broad parameter range.

This paper introduces a method to estimate human-induced changes in animal distribution and numbers by combining regression and mechanistic modeling, applied to assess offshore wind farm impacts on common murres.

This study identifies a mechanochemical feedback loop between Wnt signaling and tissue stretching that drives axis formation in Hydra regeneration.

The paper shows Notch signaling inhibits tentacle production during Hydra head regeneration, allowing hypostome/organizer formation, and identifies HyKayak as a Notch target gene.

This study uses genetic interference to investigate HvNotch's role in Hydra development, revealing its impact on regeneration, patterning, and boundary formation.

This paper uses a Cellular Potts Model to simulate cell movement and aggregation during kidney development, showing that chemoattractant secretion and cell adhesion differences drive NP cell patterning.

The paper challenges the classical Turing pattern theory by proposing two alternative frameworks for pattern formation, emphasizing far-from-equilibrium dynamics and mechano-chemical feedback.

This study shows that Hydra uses two separate patterning loops for body axis and head formation, challenging the previous single-loop model.

This study identifies HAS-7, an astacin proteinase, as a Wnt processing factor that regulates head formation in Hydra by controlling Wnt ligand activity and axis patterning.