Zhengang Yang

The paper shows that enhanced ERK signaling in human cortical radial glia drives cortical neuron expansion through interactions with PKA signaling and cell cycle regulation.

This paper shows that FGFR3 mutations cause bone shortening and brain overgrowth through ERK-mediated self-repression in different tissues.

This study identifies how ERK, PKA, YAP/TAZ, and SHH signaling integrate to drive cortical lineage diversification and evolutionary expansion in the human cerebral cortex.

This study shows that Olig1/2 knockout in gliogenesis shifts glial precursor cells to produce non-proliferative interneurons instead of oligodendrocyte precursors, and identifies dorsal cortical GPCs as origin of H3.3G34R/V-mutant tumors.

This study uses scRNA-seq and snATAC-seq to show that radial glia sequentially generate neurons and glia through lineage progression, with chromatin accessibility regulating cell fate decisions.

This study challenges the belief that lateral/caudal ganglionic eminence contributes significantly to cortical oligodendrocyte progenitor cells, showing instead that its contribution is minimal.

This study identifies ERK-BMP7-GLI3R signaling in cortical radial glial cells as a driver of mammalian cerebral cortex expansion, with implications for evolutionary dwarfism in mice.

The paper uses transcriptomic profiling and machine learning to identify 277 transcription factor networks involved in striatal neuron survival and their link to Huntington's disease.