Author

Simran Rastogi

The University of Texas Southwestern Medical CenterORCID 0000-0003-1839-1663Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Binh An NguyeniD· 2 shared Chad Dashnaw· 2 shared Charles L. WhiteiD· 2 shared Lorena SaelicesiD· 2 shared Łukasz A. JoachimiakiD· 2 shared Sarah H. ShahmoradianiD· 2 shared Isaam Memon· 1 shared Jaime Vaquer‐AliceaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBioengineering

Binh An NguyenORCID

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2 papers

Recent·Most cited

Large-Scale Mutagenesis Identifies Sequence Changes That Bias Tau Toward CTE-like Aggregation

Łukasz A. Joachimiak, Chad Dashnaw, Simran Rastogi, Nabil Morgan, Isaam Memon, Klaudia Jaczynska, Binh An Nguyen, Lorena Saelices, Charles L. White, Sarah H. Shahmoradian

The paper identifies sequence changes that bias tau aggregation toward CTE-like structures using mutagenesis and structural analysis.

bioRxiv · Oct 9, 2026 · PreprintBioengineering

Cysteines are critical determinants of spontaneous and seeded tau aggregation in cells

Łukasz A. Joachimiak, Parvathy Jayan, Simran Rastogi, Vaibhav Bommareddy, Chad Dashnaw, Jaime Vaquer‐Alicea, Binh An Nguyen, Lorena Saelices, Sarah H. Shahmoradian, Charles L. White, Marc I. Diamond

This study identifies cysteine residues as critical for tau aggregation and propagation in cells, both spontaneously and when seeded.

bioRxiv · Mar 16, 2026 · PreprintBiophysics