Vaibhav Bommareddy

This study identifies cysteine residues as critical for tau aggregation and propagation in cells, both spontaneously and when seeded.

The paper identifies amino acids critical for tau strain propagation by analyzing their role in amyloid templating across different tauopathies.

The paper uses an in silico alanine scan method to identify energetically important interactions in tau amyloid fibrils and classifies structures using machine learning.