Kate Townsend Creasy

The paper integrates chromatin accessibility data with GWAS to identify regulatory mechanisms underlying blood lipid traits, finding 20% of signals lack proposed mechanisms.

The paper identifies a cortical circuit in mice modulated by opioids and develops a gene therapy to mimic opioid analgesia for chronic pain.

This paper investigates the role of PPP1R3B in hepatic metabolism, finding it acts as a switch that promotes glycogen storage over lipid accumulation, with implications for metabolic diseases.

This study identifies VTAMOR neurons as critical modulators of low sociability during protracted opioid withdrawal and highlights their potential as a therapeutic target.

This study shows that ZHX2 activates Elovl3, which regulates cell cycle progression and is repressed in liver cancer, linking ZHX2's tumor suppressor function to VLCFA metabolism.

This study conducts a trans-ancestry GWAS using chronic ALT elevation as a proxy for NAFLD, identifies 77 significant loci, and validates 17 SNPs with histology and imaging data, revealing genetic links to metabolic and inflammatory traits.