Corinna S. Oswell

Differential modulation of aversive signaling by expectation across the cingulate cortex

The paper uses calcium imaging in mice to show that the retrosplenial cortex flexibly reorganizes during shock prediction, while the anterior cingulate cortex encodes ongoing nociception and defensive behavior.

Convergent state-control of endogenous opioid analgesia

The paper identifies a functional dichotomy in the ventrolateral periaqueductal gray, showing that micro opioid receptor neurons encode nociceptive states while enkephalin-releasing neurons drive pain relief in various contexts.

Mimicking opioid analgesia in cortical pain circuits

The paper identifies a cortical circuit in mice modulated by opioids and develops a gene therapy to mimic opioid analgesia for chronic pain.

Central amygdalar PKCδ neurons mediate fentanyl withdrawal

This study identifies PKCδ neurons in the central amygdala as key mediators of fentanyl withdrawal by showing their hyperactivity and role in withdrawal signs.

A nociceptive amygdala-striatal pathway for chronic pain aversion

This study identifies a BLAnoci ensemble in the basolateral amygdala that mediates both acute and chronic pain behavior through a novel amygdala-striatal circuit involving the nucleus accumbens shell.

An endogenous opioid circuit determines state-dependent appetitive behavior

This study identifies an endogenous opioid circuit in mice that regulates appetitive behavior through a dorsal raphe to nucleus accumbens projection.