Han Zhu

This study identifies distinct immune mechanisms in pancreatic inflammation during metabolic stress and aging using spatial and single-cell analyses.

This study shows workload-induced β-cell overstimulation leads to failure in T2D, identifying a compensating transcriptional state and the role of Lsd1 in restraining state transitions.

The paper identifies gene regulators of ER stress in beta cells and links them to type 2 diabetes risk through functional genomics and CRISPR screening.

This study identifies SIRT2 as a regulator of β-cell proliferation, showing its role in controlling β-cell expansion during hyperglycemia while preserving feedback mechanisms.

The paper identifies T1D risk genes and regulatory elements that influence beta cell survival under proinflammatory cytokine exposure using functional genomics and genetics.

The paper identifies cell fate determinants in Pax7-expressing somitic mesoderm by analyzing single-cell RNA profiles, revealing lineage-specific markers, transcription factors, and signaling pathways.