Sierra Corban

The paper integrates multiple scRNA-seq datasets to create a comprehensive atlas of human pancreatic islets, identifying 13 cell populations and providing a resource for diabetes research.

The paper identifies gene regulators of ER stress in beta cells and links them to type 2 diabetes risk through functional genomics and CRISPR screening.

This study uses single-cell and spatial profiling to identify cellular and molecular drivers of beta cell dysfunction in the pancreas of cystic fibrosis patients.

DNACipher predicts variant effects across cell types and assays, identifying imVars at most GWAS loci with support from experimental data.

This study uses single-cell multi-omics to identify cell type-specific regulatory networks and novel therapeutic targets in MASLD.

The paper integrates single-cell multi-omics and 3D genome data from human hearts to identify gene regulatory changes and causal genetic contributors in heart failure.

The paper identifies T1D risk genes and regulatory elements that influence beta cell survival under proinflammatory cytokine exposure using functional genomics and genetics.

The paper uses snATAC-seq to map chromatin accessibility QTLs in immune cell types and fine-maps complex trait loci, identifying cell type-specific causal variants.