Author

Tisha Melia

Boston UniversityORCID 0000-0003-1926-9109Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Genetics· 2 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Research Focus:clustering· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

Frequent Co-Authors

David J. WaxmaniD· 4 shared Bryan J. MatthewsiD· 1 shared Chad N. BrockeriD· 1 shared Daisuke AibaraiD· 1 shared Donghwan KimiD· 1 shared Frank J. GonzaleziD· 1 shared Jessica A. BonzoiD· 1 shared Kritika Karri· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersGenetics

David J. WaxmanORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

GeneticsPLoS GeneticsPeer-reviewedNov 9, 2021

Harnessing natural variation to identify cis regulators of sex-biased gene expression in a multi-strain mouse liver model

Bryan J. Matthews, Tisha Melia, David J. Waxman

The paper identifies cis regulators of sex-biased gene expression in mouse liver by comparing two strains and linking genetic variants to epigenetic and transcriptomic differences.

12 citations

mousebulk RNA-seq

𝕏 PostBluesky

GeneticsPLoS ONEPeer-reviewedDec 2, 2020

Genetic factors contributing to extensive variability of sex-specific hepatic gene expression in Diversity Outbred mice

Tisha Melia, David J. Waxman

This study identifies autosomal genetic factors that interact with growth hormone to regulate sex-specific gene expression in mouse liver, revealing over 200 instances of sex-specificity changes across strains.

19 citations

mousebulk RNA-seq

𝕏 PostBluesky

Molecular BiologyNature CommunicationsPeer-reviewedNov 17, 2020

Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to metabolic stress

Chad N. Brocker, Donghwan Kim, Tisha Melia…·Frank J. Gonzalez

The paper shows that PPARA upregulates Gm15441, which suppresses TXNIP and reduces NLRP3 inflammasome activation during metabolic stress.

90 citationstop 3%

mouseexperimental assay

𝕏 PostBluesky

Systems BiologyEndocrinologyPeer-reviewedMar 6, 2019

Sex-biased long non-coding RNAs negatively correlated with sex-opposite protein coding gene co-expression networks in Diversity Outbred mouse liver

Tisha Melia, David J. Waxman

The paper identifies sex-biased lncRNAs in mouse liver that negatively correlate with opposite-sex protein-coding gene co-expression modules related to hypox responsiveness.

29 citations

mousebulk RNA-seq

𝕏 PostBluesky