Author

Frank J. Gonzalez

National Institutes of HealthORCID 0000-0002-7990-2140Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Molecular Biology· 2 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Donghwan KimiD· 2 shared Shogo TakahashiiD· 2 shared Alexander Cain· 1 shared Amanda Huber· 1 shared Andrew Bynum· 1 shared Andrew D. PattersoniD· 1 shared Andrew S. I. LoudoniD· 1 shared Anitha Vijay Mallappa· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMolecular Biology

Donghwan KimORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

D-Mannose treats obesity by increasing adipose Treg cells and suppressing gut Firmicutes

Peter Zanvit, Junji Xu, Nancy Guo, Dunfang Zhang, Michaela Procházková, Thierry Gauthier, Daxesh P. Patel, Alexander Cain, Wenwen Jin, Andrew Bynum, Frank J. Gonzalez, Yasmine Belkaid, WanJun Chen

This study shows that D-mannose reduces obesity in mice by enhancing adipose Treg cells and decreasing gut Firmicutes bacteria.

bioRxiv · Aug 18, 2026 · PreprintImmunology

Fatty acids in the tumor microenvironment reprogram neutrophils to induce immunosuppression via adenosine

Rashi Singhal, Nina W. Zhang, Zheng Hong Lee, Hannah Noelle Bell, Prarthana Dalal, Sumeet A. Solanki, Wesley Huang, Ryan James Rebernick, Peter Sajjakulnukit, Himani Jasewicz, Roshan Kumar, Nikhil Kumar Kotla, Amanda Huber, Anitha Vijay Mallappa, Subhash B. Arya, , Yatrik Madhukar Shah

This study identifies a fatty acid-driven neutrophil-adenosine axis that promotes immunosuppression in colorectal cancer and shows that targeting adenosine receptors can enhance immunotherapy responses.

bioRxiv · Apr 6, 2026 · PreprintCancer Biology

HNF4A is required to specify glucocorticoid action in the liver

Louise Hunter, Toryn M. Poolman, Donghwan Kim, Frank J. Gonzalez, David A. Bechtold, Andrew S. I. Loudon, Mudassar Iqbal, David William Ray

This study shows HNF4A is essential for liver-specific GR action, with HNF4A regulating GR binding sites and transcriptional response to glucocorticoids in the liver.

bioRxiv · Apr 10, 2021 · PreprintMolecular Biology

Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to metabolic stress

Chad N. Brocker, Donghwan Kim, Tisha Melia, Kritika Karri, Thomas J. Velenosi, Shogo Takahashi, Daisuke Aibara, Jessica A. Bonzo, Moshe Levi, David J. Waxman, Frank J. Gonzalez

The paper shows that PPARA upregulates Gm15441, which suppresses TXNIP and reduces NLRP3 inflammasome activation during metabolic stress.

Nature Communications · Nov 17, 2020Peer-reviewedMolecular Biology