Bryan J. Matthews

This study develops regRNA Capture-seq to profile regulatory RNAs and demonstrates that targeting these RNAs with ASOs can upregulate gene expression in hepatocytes.

This study assesses iPSC-derived microglia-like cells using bulk and single-cell RNA sequencing, showing they resemble primary human microglia in gene expression and respond to LXR agonists.

The paper identifies cis regulators of sex-biased gene expression in mouse liver by comparing two strains and linking genetic variants to epigenetic and transcriptomic differences.

The paper identifies subTADs formed by CTCF and cohesin in mouse liver, showing they functionally resemble TADs and restrict enhancer-promoter interactions.