Author

Wren E. Michaels

Rosalind Franklin University of Medicine and ScienceORCID 0000-0003-1928-7956Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Michelle L. HastingsiD· 2 shared Robert J. Bridges· 2 shared Cecilia Peña‐RasgadoiD· 1 shared Elvia Rodriguez-Manriquez· 1 shared Miroslav DundriD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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2 shared papersMolecular Biology

Michelle L. HastingsORCID

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2 papers

Recent·Most cited

Molecular BiologyNAR Molecular MedicinePeer-reviewedOct 1, 2024

Systematic deletion of symmetrical CFTR exons reveals new therapeutic targets for exon skipping antisense oligonucleotides

Cecilia Peña‐Rasgado, Elvia Rodriguez-Manriquez, Miroslav Dundr…·Wren E. Michaels

This study identifies therapeutic targets for exon skipping antisense oligonucleotides by systematically analyzing CFTR isoforms generated through symmetrical exon deletion.

2 citations

humanexperimental assay

𝕏 PostBluesky

Molecular BiologyNucleic Acids ResearchPeer-reviewedJun 5, 2020

Antisense oligonucleotide-mediated correction of CFTR splicing improves chloride secretion in cystic fibrosis patient-derived bronchial epithelial cells

Wren E. Michaels, Robert J. Bridges, Michelle L. Hastings

This study shows that an antisense oligonucleotide corrects a CFTR splicing mutation in patient-derived cells, improving chloride secretion and outperforming ivacaftor.

51 citationstop 3%

humanexperimental assay

𝕏 PostBluesky