Author

Michelle L. Hastings

Rosalind Franklin University of Medicine and ScienceORCID 0000-0002-4253-9261Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Organism:plant (other)· 1

Frequent Co-Authors

Fox J. Duelli· 2 shared Jessica L. CentaiD· 2 shared Robert J. Bridges· 2 shared Wren E. MichaelsiD· 2 shared Arlene V. DrackiD· 1 shared Cecilia Peña‐RasgadoiD· 1 shared Christopher D. PutnamiD· 1 shared Clarissa D. Booth· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMolecular Biology

Fox J. Duelli

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Modulating NLRP3 splicing with antisense oligonucleotides to control pathological inflammation

Roni Klein, Janset Onyuru, Jessica L. Centa, Estela M. Viera, Fox J. Duelli, Christopher D. Putnam, Hal M. Hoffman, Michelle L. Hastings

This study uses antisense oligonucleotides to modulate NLRP3 splicing, reducing its inflammatory activity and systemic inflammation in mouse models.

Nucleic Acids Research · Oct 28, 2025Peer-reviewedMolecular Biology

Therapeutic antisense oligonucleotide mitigates retinal dysfunction in a pig model of CLN3 Batten disease

Matthew P. Stratton, Jessica L. Centa, Vicki J. Swier, Wanda L. Pfeifer, Clarissa D. Booth, Karlee Albert, John L. Hunyara, Mitchell J. Rechtzigel, Fox J. Duelli, Hannah G. Leppert, Frank Rigo, Trisha Smit, Paymaan Jafar‐Nejad, Jill M. Weimer, Arlene V. Drack, Michelle L. Hastings

A splice-switching antisense oligonucleotide delivered via intravitreal injection mitigates early retinal dysfunction in a pig model of CLN3 Batten disease.

Nucleic Acids Research · Oct 16, 2025Peer-reviewedMolecular Biology

Systematic deletion of symmetrical CFTR exons reveals new therapeutic targets for exon skipping antisense oligonucleotides

Cecilia Peña‐Rasgado, Elvia Rodriguez-Manriquez, Miroslav Dundr, Robert J. Bridges, Michelle L. Hastings, Wren E. Michaels

This study identifies therapeutic targets for exon skipping antisense oligonucleotides by systematically analyzing CFTR isoforms generated through symmetrical exon deletion.

NAR Molecular Medicine · Oct 1, 2024Peer-reviewedMolecular Biology

Antisense oligonucleotide-mediated correction of CFTR splicing improves chloride secretion in cystic fibrosis patient-derived bronchial epithelial cells

Wren E. Michaels, Robert J. Bridges, Michelle L. Hastings

This study shows that an antisense oligonucleotide corrects a CFTR splicing mutation in patient-derived cells, improving chloride secretion and outperforming ivacaftor.

Nucleic Acids Research · Jun 5, 2020Peer-reviewedMolecular Biology