Timothy R. D. J. Radstake

This study uses scRNA-seq and flow cytometry to analyze immune cell changes in psoriasis patients, revealing altered immune signatures in blood and skin.

The paper identifies a core gene network linked to inflammation and hyper-keratinization in psoriatic skin, associated with disease severity and microbiome composition.

RegEnrich identifies key gene regulators using a data-driven approach, revealing ETS transcription factors' role in interferon signaling.

This study shows CXCL4 drives inflammation and fibrosis by altering monocyte-derived cell differentiation through transcriptional and epigenetic changes.

The paper identifies top disease-associated cells and genes in IMIDs and proposes drug repurposing targets using a DIME network approach.

This study quantifies DNA damage and telomere length in keratoconus corneas to assess oxidative stress and replicative stress, finding no significant DNA damage differences but longer telomeres in keratoconus.

This study identifies functionally distinct ERAP1 and ERAP2 haplotypes associated with Birdshot Uveitis and shows their combined effect enhances disease risk.

The paper identifies up-regulation of the mTORC1 pathway in keratoconus corneas and confirms differential expression of GWAS risk loci.

The paper identifies serine-11 in HLA-DRB1 as a risk factor for uveitis in JIA, showing sex-specific association and peptide-binding preferences.