Synthetic BiologybioRxivPreprint
In vitro selection of Engineered Transcriptional Repressors for targeted epigenetic silencing and initial evaluation of their specificity profile
Alessandro Migliara, Martino Alfredo Cappelluti, Sara Valsoni…·Angelo Lombardo
The paper describes an in vitro screening protocol to identify effective gRNAs for epigenetic silencing using engineered transcriptional repressors and evaluates their genome-wide specificity.
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