TASOR expression in naive embryonic stem cells safeguards their developmental potential
Carlos A. Pinzón-Arteaga, Ryan A. O’Hara, Alice Mazzagatti, Emily B. Ballard, Yingying Hu, Alex Pan, Daniel A. Schmitz, Yulei Wei, Masahiro Sakurai, Peter Ly, Laura A. Banaszynski, Jun Wu
This study identifies TASOR's role in maintaining developmental potential during the transition from naive to primed pluripotency by preventing L1 transposable element activation and subsequent cell death.
Cell Reports · Oct 24, 2024Peer-reviewedDevelopmental Biology