Qiang Pan‐Hammarström

The paper maps the tumor microenvironment in DLBCL using imaging mass cytometry and finds that immune-cell depleted tumors have reduced MHC-I expression and worse survival.

This study identifies lipid-laden macrophages as an immunosuppressive niche in PCNSL, validated through spatial transcriptomics and mouse models, and shows SYK inhibition reverses their tumor-supportive activity.

This study identifies IL-16 production as a mechanism of resistance to BTK inhibitors and R-CHOP in lymphomas, showing that targeting the IL-16/CD9 axis restores drug sensitivity.

This study maps human B-cell populations and their interactions across 10 tissues using single-cell RNA sequencing, revealing tissue-specific adaptations and residency gene modules.

RareFold predicts and designs protein structures with noncanonical amino acids, achieving low-micromolar affinities and no immune activation in organoid models.

The paper identifies rare loss-of-function variants in type I IFN immunity genes associated with severe COVID-19, particularly in younger patients with recessive inheritance.

The paper introduces BPHunter, a computational tool to detect intronic variants disrupting branchpoints, identifies known and novel mutations, and validates them experimentally.

The paper identifies hundreds of genes deregulated by SVs in cancer, showing increased expression linked to SV breakpoints and enhancer elements.

The paper analyzes RNA alterations across 27 cancer types using whole-genome sequencing data, identifying gene expression associations with DNA variants and structural fusions.