Matthew D Thompson

The paper shows BG4 CUT&Tag and untargeted CUT&Tag signals are both enriched at G-quadruplexes and accessible chromatin, suggesting BG4 CUT&Tag may not reliably distinguish G4s from other accessible regions.

The paper identifies a rare SNP in the HELB gene that disrupts its interaction with RPA and affects age at natural menopause through impaired DNA repair function.