Author

Kirk L. West

University of Arkansas for Medical SciencesORCID 0000-0002-9894-4549Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:host-pathogen & immune response· 1 Organism:rat· 1 Approach:statistical model· 1

Frequent Co-Authors

Alicia K. ByrdiD· 1 shared Benjamin H May· 1 shared Benjamin J. HarrisoniD· 1 shared Bertha OseiiD· 1 shared Duah AlkamiD· 1 shared Eric Christian RouchkaiD· 1 shared Eric J. EnemarkiD· 1 shared Erik Bergstrom· 1 shared

Activity by Year

2017-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperBiochemistry

Alicia K. ByrdORCID

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Author profile →

3 papers

Recent·Most cited

Rare SNP in the HELB gene interferes with RPA interaction and cellular function of HELB

Bertha Osei, Benjamin H May, Joseph S Beard, Matthew D Thompson, Duah Alkam, Maroof Khan Zafar, Erik Bergstrom, Stephanie D. Byrum, Eric J. Enemark, Kirk L. West, Alicia K. Byrd

The paper identifies a rare SNP in the HELB gene that disrupts its interaction with RPA and affects age at natural menopause through impaired DNA repair function.

NAR Molecular Medicine · Mar 29, 2025Peer-reviewedBiochemistry

Autophosphorylation of the Tousled-like kinases TLK1 and TLK2 regulates recruitment to damaged chromatin via PCNA interaction

Kirk L. West, Tram T N Nguyen, Kyle Tengler, Natasha F. Kreiling, Kevin D. Raney, Gargi Ghosal, Justin W. C. Leung

This study shows that TLK1 and TLK2 hyper-autophosphorylation suppresses their recruitment to damaged chromatin by masking the PIP-box, which is required for PCNA interaction.

Nucleic Acids Research · Dec 13, 2024Peer-reviewedGenetics

Framework For Reanalysis Of Publicly Available Affymetrix(R) Genechip(R) Data Sets Based On Functional Regions Of Interest

Ernur Saka, Benjamin J. Harrison, Kirk L. West, Jeffrey C. Petruska, Eric Christian Rouchka

The paper presents a framework for reanalyzing Affymetrix GeneChip data using functional regions of interest, improving probe mapping and detection of gene expression changes.

BMC Genomics · Dec 1, 2017Peer-reviewedBioinformatics