Author

Duah Alkam

University of Arkansas for Medical SciencesORCID 0000-0002-5965-7694Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Stephanie D. ByrumiD· 2 shared Alan J. TackettiD· 1 shared Alicia K. ByrdiD· 1 shared Benjamin H May· 1 shared Bertha OseiiD· 1 shared Charity L. WashamiD· 1 shared Eric J. EnemarkiD· 1 shared Erik Bergstrom· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

Stephanie D. ByrumORCID

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2 papers

Recent·Most cited

Rare SNP in the HELB gene interferes with RPA interaction and cellular function of HELB

Bertha Osei, Benjamin H May, Joseph S Beard, Matthew D Thompson, Duah Alkam, Maroof Khan Zafar, Erik Bergstrom, Stephanie D. Byrum, Eric J. Enemark, Kirk L. West, Alicia K. Byrd

The paper identifies a rare SNP in the HELB gene that disrupts its interaction with RPA and affects age at natural menopause through impaired DNA repair function.

NAR Molecular Medicine · Mar 29, 2025Peer-reviewedBiochemistry

Proteogenomics analysis to identify acquired resistance-specific alterations in melanoma PDXs on MAPKi therapy

Kanishka Manna, Prashanthi Dharanipragada, Duah Alkam, Nathan L. Avaritt, Charity L. Washam, Michael Scott Robeson, Tung-Chin Chiang, Ricky D. Edmondson, Samuel Mackintosh, Zhentao Yang, Yan Wang, Shirley Lomeli, Gatien Moriceau, Stephanie D. Byrum, Roger S. Lo, Alan J. Tackett

The paper presents a proteogenomic approach to identify resistance-specific alterations in melanoma PDX models treated with MAPK inhibitors using custom curated databases.

bioRxiv · Feb 15, 2022 · PreprintBioinformatics