Jea Kwon

The paper shows that astrocytic Best1 mediates a switch in tonic inhibition in cerebellar granule cells during adolescence, enhancing motor coordination through network-level changes.

SUBTLE maps animal behavior from 3D action skeletons using an unsupervised framework, achieving superior performance in capturing behavioral repertoires and identifying inter-group differences through temporal representation.

This study identifies GABRA5-positive neurons in the lateral hypothalamic area that regulate obesity through astrocytic GABA release, showing that inhibiting astrocytic GABA reduces weight gain.

The paper demonstrates that PET/CT imaging with 11C-acetate and 18F-FDG can visualize reactive astrocyte-mediated neuronal hypometabolism in Alzheimer's disease.

This study shows that astrocytic urea cycle detoxifies Aβ-derived ammonia but impairs memory in Alzheimer's disease, suggesting ODC1 inhibition as a potential therapeutic strategy.