Melanie van der Woude

RNA polymerase II processing facilitates DNA repair and prevents DNA damage-induced neuronal and developmental failure

This study shows that RNA polymerase II processing prevents DNA damage-induced neuronal and developmental failure in TC-NER defects by enabling backup repair pathways.

Recovery of protein synthesis to measure transcription-coupled DNA repair in living cells and tissues

The paper introduces a new assay, Recovery of Protein Synthesis (RPS), to measure TC-NER by tracking protein synthesis recovery after DNA damage, showing its utility in living cells and tissues.

C. elegans TFIIH subunit GTF-2H5/TTDA is a non-essential transcription factor indispensable for DNA repair

This study shows that GTF-2H5 is essential for DNA repair in C. elegans but not for viability, highlighting its role in transcription and repair processes.