Jurgen A. F. Marteijn

The paper shows that helicase-deficient TFIIH causes severe disease by trapping DNA in a futile repair cycle, leading to persistent excision without lesion removal.

This study shows CDK12 inhibition both downregulates and upregulates gene expression, with implications for cancer therapy.

This study shows that RNA polymerase II processing prevents DNA damage-induced neuronal and developmental failure in TC-NER defects by enabling backup repair pathways.

This study identifies STK19 as a critical factor in transcription-coupled nucleotide excision repair by stabilizing the repair complex and promoting Pol II ubiquitylation and TFIIH recruitment.