Wim Vermeulen

The paper shows that helicase-deficient TFIIH causes severe disease by trapping DNA in a futile repair cycle, leading to persistent excision without lesion removal.

This study shows that RNA polymerase II processing prevents DNA damage-induced neuronal and developmental failure in TC-NER defects by enabling backup repair pathways.

This study investigates how XPG function is regulated during nucleotide excision repair through dynamic interactions with TFIIH, XPA, and EXO1, revealing mechanisms of XPG recruitment and dissociation from DNA damage.

This study identifies STK19 as a critical factor in transcription-coupled nucleotide excision repair by stabilizing the repair complex and promoting Pol II ubiquitylation and TFIIH recruitment.

The paper introduces a new assay, Recovery of Protein Synthesis (RPS), to measure TC-NER by tracking protein synthesis recovery after DNA damage, showing its utility in living cells and tissues.

This study shows that GTF-2H5 is essential for DNA repair in C. elegans but not for viability, highlighting its role in transcription and repair processes.