Author

Alex J. McCann

The University of QueenslandORCID 0000-0002-2984-5782Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Approach:microscopy & imaging analysis· 2 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Organism:Drosophila· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

Frederic A. MeunieriD· 3 shared Adekunle T. BademosiiD· 2 shared Elizabeth HindeiD· 2 shared Mathias FrançoisiD· 2 shared Patrik VerstrekeniD· 2 shared Alexander O. WardiD· 1 shared Barbara E Duda· 1 shared Benjamin KroegeriD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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3 shared papersNeuroscience

Frederic A. MeunierORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Single-molecule bouncing at a liquid interface governs presynaptic enrichment

Kye Kudo, Shanley F. Longfield, Alex J. McCann, Nils Schoovaerts, Julissa Sanchez-Velasquez, Leonardo A. Parra-Rivas, Subhojit Roy, Patrik Verstreken, Elizabeth Hinde, S. Sean Millard, Adekunle T. Bademosi, Frederic A. Meunier

The paper shows that single-molecule bouncing at a presynaptic interface enables protein enrichment without slowing diffusion.

bioRxiv · Nov 2, 2026 · PreprintNeuroscience

Transmitted alpha-synuclein extracellular vesicles downregulate axonal flux of retrograde carriers in recipient neurons

Barbara E Duda, Saber H. Saber, Vanessa Lanoue, Adekunle T. Bademosi, Rachel S. Gormal, Tristan P. Wallis, Alex J. McCann, Yara Abosnwber, Justin John Cooper-White, Patrik Verstreken, Frédéric A. Meunier

This study shows that transmitted alpha-synuclein extracellular vesicles reduce retrograde axonal transport in recipient neurons, with effects dependent on endogenous alpha-synuclein interaction.

bioRxiv · Sep 22, 2025 · PreprintNeuroscience

NKX2-5 congenital heart disease mutations show diverse loss and gain of epigenomic, biochemical and chromatin search functions underpinning pathogenicity

Alexander O. Ward, Nicole Schönrock, Alex J. McCann, Sabrina K. Phanor, Kian Hong Kock, Jesse V. Kurland, Fujian Wu, Nicholas J. Murray, James L. Walshe, Dimuthu Alankarage, Sally L. Dunwoodie, Frédéric A. Meunier, Mathias François, Martha L. Bulyk, Mirana Ramialison, Richard Paul Harvey

The paper investigates NKX2-5 mutations in congenital heart disease by analyzing their epigenomic, biochemical, and chromatin search functions in cardiomyocytes, revealing diverse loss and gain-of-function defects.

bioRxiv · Jun 20, 2025 · PreprintGenomics

Hippo signalling regulates the nuclear behaviour and DNA dwell times of YAP and TEAD to control transcription

Benjamin Kroeger, Samuel A. Manning, Varshini Mohan, Qiji Deng, Jieqiong Lou, Guizhi Sun, Sara Lamont, Alex J. McCann, Mathias François, Jose Maria Polo, Elizabeth Hinde, Kieran F. Harvey

This study uses live microscopy to show that Hippo signalling regulates transcription by controlling the DNA dwell times of YAP and TEAD proteins.

bioRxiv · Mar 11, 2025 · PreprintCell Biology