Author

Ke Chen

University of California San DiegoORCID 0000-0003-2089-1288Unclaimed ORCID profile · follow to get notified of new preprints

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Ke Chen5 papers · BGI Research

Biology Disciplines

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Systems Biology· 2

Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Adam M. FeistiD· 2 shared Arjun PateliD· 2 shared Bernhard Ørn PalssoniD· 2 shared Connor A. OlsoniD· 2 shared Richard SzubiniD· 2 shared Ying HefneriD· 2 shared Amitesh AnandiD· 1 shared Cameron R. Lamoureux· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersSystems Biology

Adam M. FeistORCID

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2 papers

Recent·Most cited

Systems BiologyGenome Biology and EvolutionPeer-reviewedSep 30, 2025

Laboratory evolution reveals transcriptional mechanisms underlying thermal adaptation of Escherichia coli

Kevin Rychel, Ke Chen, Edward Catoiu…·Bernhard Ørn Palsson

This study uses adaptive laboratory evolution to identify five transcriptional mechanisms enabling Escherichia coli to grow at high temperatures.

8 citationstop 4%

E. colibulk RNA-seq

𝕏 PostBluesky

Systems BiologyNature CommunicationsPeer-reviewedJun 27, 2022

Laboratory evolution of synthetic electron transport system variants reveals a larger metabolic respiratory system and its plasticity

Amitesh Anand, Arjun Patel, Ke Chen…·Bernhard Ørn Palsson

The paper evolves ETS variants in E. coli and finds they all optimize growth rate and proteome allocation, with conserved aero-type strategies except for ETS-4H.

30 citations

E. coliexperimental assay

𝕏 PostBluesky