Arjun Patel

This study shows that E. coli lacking NADH dehydrogenases adapts by derepressing malate:quinone oxidoreductase, restoring oxidative metabolism through an alternative respiratory pathway.

The paper identifies an aerobicity stimulon in E. coli through computational analysis of evolved respiratory variants, showing gene groups co-regulated with aerobic capacity and proteome reallocation.

This study uses adaptive laboratory evolution to identify five transcriptional mechanisms enabling Escherichia coli to grow at high temperatures.

The paper demonstrates that Escherichia coli can utilize extracellular electron transfer via 2-hydroxy-1,4-naphthoquinone to support anaerobic growth, revealing a new energy metabolism pathway.

The paper uses adaptive laboratory evolution and transcriptomic analysis to identify six mechanisms of paraquat tolerance in E. coli.

The paper evolves ETS variants in E. coli and finds they all optimize growth rate and proteome allocation, with conserved aero-type strategies except for ETS-4H.