Lenacapavir binding to immature Gag triggers the emergence of giant HIV-1 virions
Wright Andrews Ofotsu Amesimeku, Yoshihiro Nakata, Nami Monde, Hiromi Terasawa, Hirotaka Ode, Hiroyuki Sasaki, Takeshi Matsui, Perpetual Nyame, Md Jakir Hossain, Akatsuki Saito, Tomohiro Sawa, Terumasa Ikeda, Yosuke Maeda, Yasumasa Iwatani, Kazuaki Monde
The paper shows lenacapavir binding to immature Gag leads to non-infectious giant HIV-1 virions with altered structure and function.
bioRxiv · Jul 16, 2025 · PreprintMicrobiology