Daniel Aletaha

This study uses scRNA-seq and immunophenotyping to analyze immune changes in RA patients on MTX, showing early restoration of naive T/B cells and reduced memory T cells, with plasmablasts as a potential biomarker.

This study identifies NNMT as a key driver of fibroblast activation and skin fibrosis in systemic sclerosis by modulating TGFβ signaling and ECM production.

This study screens histone acetylation inhibitors to modulate immune pathways in RA, showing concentration-dependent effects and overlap with existing RA drug pathways.