Michael Markus Bonelli

This study identifies SSc synovitis as an IFN-driven stromal condition distinct from RA, with implications for IFNAR1 blockade as a therapeutic strategy.

This study uses scRNA-seq and immunophenotyping to analyze immune changes in RA patients on MTX, showing early restoration of naive T/B cells and reduced memory T cells, with plasmablasts as a potential biomarker.

This study identifies primulagenin A as a potent inverse agonist of RORγ, showing efficacy in inhibiting Th17 cell differentiation and reducing IL-17A production.

SummArIzeR clusters and annotates cross-database enrichment results using large language models, providing fast and unbiased interpretation of biological data.

This study shows that regulatory T cells can maintain suppressive function and a Treg signature even when Foxp3 expression is lost in Th2-driven disease models.

This study screens histone acetylation inhibitors to modulate immune pathways in RA, showing concentration-dependent effects and overlap with existing RA drug pathways.